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Peptide therapy

Prescribed when the panel asks. Not before.

Six classes, each graded by how strong the human evidence actually is.

classes, every one graded
6classes, every one graded
sold as a package, ever
0sold as a package, ever
decides, not a request and not a trend
Paneldecides, not a request and not a trend
First, plainly

The body already speaks this language.

  • 01

    What they are

    Short chains of amino acids, the same units the body builds every protein and hormone from. Short enough to act as a message rather than as a structure.

  • 02

    How they work

    Each one has a shape that fits a particular receptor on a particular cell, and that fit triggers one response. The body already runs on this. A peptide protocol borrows the mechanism deliberately.

  • 03

    Why the precision cuts both ways

    A narrow target means a narrow effect. Matched to the right problem, that is the advantage. Matched to the wrong one, it does nothing at all, which is most of what the grey market sells.

One distinction to hold onto: a peptide is not a vitamin and not a supplement. Used clinically it is a prescription medicine, even when the sequence is one your own body makes. Anyone selling you it as wellness has skipped the part where a doctor decides.

The classes

Six classes. Graded by what is actually known.

The limit comes before the promise on every one of these, because the limit is the part nobody else will show you.

Preclinical2 of 6 classesTissue repairLongevity and mitochondrialEmerging1 of 6 classesGrowth hormone axisTrialled2 of 6 classesImmune modulationSexual and reproductive axisApproved1 of 6 classesMetabolic regulatorsWeakest evidence on the left → strongest on the right
Approved

Licensed by a major regulator for a named condition, on the back of completed human trials.

Trialled

Randomised human trials exist and are published, but the molecule is not licensed for this use.

Emerging

Small human studies or a single research group. Real signal rather than yet a settled answer.

Preclinical

Animal or laboratory data only. No published randomised human trial.

  • Approved

    Metabolic regulators

    GLP-1 and related incretins

    Semaglutide, tirzepatide

    Blunt appetite signalling and slow gastric emptying, which moves weight, glucose control and the lipid picture together.

    The limit

    The strongest evidence base on this page, and the most over-prescribed class in the region. It treats a metabolic problem; it does not treat wanting to be thinner.

    Considered when

    Insulin resistance, HbA1c or body composition that has not moved on a real training and nutrition plan.

  • Emerging

    Growth hormone axis

    Secretagogues

    Tesamorelin, sermorelin, ipamorelin, CJC-1295

    Prompt the body's own growth hormone release rather than replacing it, with the intent of supporting recovery, body composition and sleep.

    The limit

    These reliably move IGF-1 on a blood test. Whether moving IGF-1 makes a healthy adult better at anything is a separate question, and it has not been answered. Tesamorelin is the only one licensed anywhere, for one specific condition.

    Considered when

    A documented deficit on the panel alongside a clinical picture. Never for cosmetic or performance reasons.

  • Preclinical

    Tissue repair

    Regenerative signalling

    BPC-157, TB-500

    Widely used after soft-tissue injury and surgery on the strength of animal work and clinical anecdote.

    The limit

    After three decades of animal work, BPC-157 has no approved formulation, no validated dose and no completed phase II trial. If somebody sells you this as proven, they have not read it.[2]

    Considered when

    Considered only alongside physiotherapy and rehabilitation, for an identified injury, with the state of the evidence put in writing first.

  • Trialled

    Immune modulation

    Thymic peptides

    Thymosin alpha-1

    Regulates immune response. Trialled in hepatitis B and C, sepsis and aspergillosis, and used in thousands of patients.

    The limit

    Registered in a number of countries, but not licensed by the FDA or the EMA, which is why it is graded trialled here rather than approved. Dose, schedule and what to measure remain unsettled, and the evidence in otherwise healthy adults is thin, exactly the population most likely to be sold it.[1]

    Considered when

    Inflammatory and immune markers that are genuinely abnormal rather than a run of ordinary winters.

  • Trialled

    Sexual and reproductive axis

    Melanocortin and kisspeptin

    Bremelanotide, kisspeptin-54

    Act on the brain's desire and reproductive-axis pathways rather than on blood flow, which is what separates them from the familiar tablets.

    The limit

    Bremelanotide is licensed for one condition in women. Kisspeptin has real trial data, and the short grey-market form sold online is not the form that was studied.

    Considered when

    A hormonal panel and a history that support it, after the ordinary causes have been ruled out.

  • Preclinical

    Longevity and mitochondrial

    Cellular signalling

    Epitalon, MOTS-c

    Target the cellular-ageing and mitochondrial pathways that longevity research is currently most interested in.

    The limit

    Mouse data and one or two small studies from single research groups. This is the class with the biggest gap between how it is marketed and what is known, and it is the class Orba is slowest to reach for.

    Considered when

    Only for someone already doing the things that are proven: strength, cardiorespiratory fitness, sleep, metabolic health, and told plainly that this is the speculative end.

The rules

Four rules we do not bend.

Not disclaimers. This is how you can tell whether any peptide programme, ours or anyone’s, is being run as medicine or as retail.

  • The panel decides. Neither you nor we do

    A peptide is proposed when your results show a specific thing to correct. Asking for one by name is not an indication, and neither is reading about it. If the data does not support it, you will be told no and told why.

  • You are told what is known before you decide

    Every class on this page carries an evidence grade, and you get it in writing before anything is prescribed, including when the honest grade is 'nobody has tested this in people'. Consent that skips that is not consent.

  • Prescribed against a marker, reviewed against the same marker

    Whatever justified the prescription is what gets re-measured. If it has not moved by the review, the prescription stops. A protocol does not continue because you have got used to it.

  • Never part of a package

    Peptides are not in a membership tier, a retreat or an experience. They are individual prescriptions, individually justified. A clinic that bundles them has decided what you need before it met you.

Where we are with this

Prescribing peptides in Thailand runs through a licensed physician and a licensed compounding pharmacy, with a certificate of analysis on every batch. Orba is putting that chain in place, the licence and a supplier we are willing to put our name to, and will not prescribe from this page until both are done. Other Bangkok clinics work this way already; we would rather be late than be sourcing from somewhere we cannot audit.

Until then, this page exists so you can judge the evidence for yourself, and judge anyone else who offers you these.

What people ask.

Before anything is prescribed, and often instead of it.

References

  1. 1.Camerini, R., & Garaci, E. (2015). Historical review of thymosin α1 in infectious diseases. Expert Opinion on Biological Therapy. PMID:26098768
  2. 2.Mateescu, D. M., et al. (2026). BPC-157 as an investigational peptide therapeutic: biopharmaceutical challenges, formulation strategies, and translational development barriers. Pharmaceutics. PMID:42198317
Start with the baseline

The method only works from a measurement.

Everything above starts at the same place: one visit that maps where you actually are. What follows is decided by what that visit finds.

See the full protocol

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